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A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy
Scalable and efficient production of high-quality recombinant adeno-associated virus (rAAV) for gene therapy remains a challenge despite recent clinical successes. We developed a new strategy for scalable and efficient rAAV production by sequestering the AAV helper genes and the rAAV vector DNA in t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711426/ https://ncbi.nlm.nih.gov/pubmed/23677609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt404 |
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