Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites

N6-methyladenosine (m6A) is a common modification of mRNA, with potential roles in fine-tuning the RNA life-cycle. Here, we identify a dense network of proteins interacting with METTL3, a component of the methyltransferase complex, and show that three of them, WTAP, METTL14 and KIAA1429, are require...

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Autors principals: Schwartz, Schraga, Mumbach, Maxwell R., Jovanovic, Marko, Wang, Tim, Maciag, Karolina, Bushkin, G. Guy, Mertins, Philipp, Ter-Ovanesyan, Dmitry, Habib, Naomi, Cacchiarelli, Davide, Sanjana, Neville E., Freinkman, Elizaveta, Pacold, Michael E., Satija, Rahul, Mikkelsen, Tarjei S., Hacohen, Nir, Zhang, Feng, Carr, Steven A., Lander, Eric S., Regev, Aviv
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142486/
https://ncbi.nlm.nih.gov/pubmed/24981863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.048
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