Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

SUMMARY: Intestinal microbial metabolites are conjectured to affect mucosal integrity through an incompletely characterized mechanism. Here we showed microbial-specific indoles regulated intestinal barrier function through the xenobiotic sensor, pregnane X receptor (PXR). Indole 3-propionic acid (IP...

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Main Authors: Venkatesh, Madhukumar, Mukherjee, Subhajit, Wang, Hongwei, Li, Hao, Sun, Katherine, Benechet, Alaxandre P., Qiu, Zhijuan, Maher, Leigh, Redinbo, Matthew R., Phillips, Robert S., Fleet, James C., Kortagere, Sandhya, Mukherjee, Paromita, Fasano, Alessio, Le Ven, Jessica, Nicholson, Jeremy K., Dumas, Marc E., Khanna, Kamal M., Mani, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142105/
https://ncbi.nlm.nih.gov/pubmed/25065623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.06.014
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