Integrin Receptors on Tumor Cells Facilitate NK cell-mediated Antibody-dependent Cytotoxicity

NK cells that mediate ADCC play an important role in tumor-specific immunity. We have examined factors limiting specific lysis of tumor cells by CD16.NK-92 cells induced by CNTO 95LF antibodies recognizing α(V) integrins that are overexpressed on many tumor cells. Although all tested tumor cells wer...

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Bibliografiske detaljer
Main Authors: Anikeeva, Nadia, Steblyanko, Maria, Fayngerts, Svetlana, Kopylova, Natalya, Marshall, Deborah J., Powers, Gordon D., Sato, Takami, Campbell, Kerry S, Sykulev, Yuri
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141007/
https://ncbi.nlm.nih.gov/pubmed/24810893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201344179
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