Porphyromonas gingivalis-derived Lysine Gingipain Enhances Osteoclast Differentiation Induced by Tumor Necrosis Factor-α and Interleukin-1β but Suppresses That by Interleukin-17A: IMPORTANCE OF PROTEOLYTIC DEGRADATION OF OSTEOPROTEGERIN BY LYSINE GINGIPAIN

Periodontitis is a chronic inflammatory disease accompanied by alveolar bone resorption by osteoclasts. Porphyromonas gingivalis, an etiological agent for periodontitis, produces cysteine proteases called gingipains, which are classified based on their cleavage site specificity (i.e. arginine (Rgps)...

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Détails bibliographiques
Auteurs principaux: Akiyama, Tomohito, Miyamoto, Yoichi, Yoshimura, Kentaro, Yamada, Atsushi, Takami, Masamichi, Suzawa, Tetsuo, Hoshino, Marie, Imamura, Takahisa, Akiyama, Chie, Yasuhara, Rika, Mishima, Kenji, Maruyama, Toshifumi, Kohda, Chikara, Tanaka, Kazuo, Potempa, Jan, Yasuda, Hisataka, Baba, Kazuyoshi, Kamijo, Ryutaro
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140917/
https://ncbi.nlm.nih.gov/pubmed/24755218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520510
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