Porphyromonas gingivalis-derived Lysine Gingipain Enhances Osteoclast Differentiation Induced by Tumor Necrosis Factor-α and Interleukin-1β but Suppresses That by Interleukin-17A: IMPORTANCE OF PROTEOLYTIC DEGRADATION OF OSTEOPROTEGERIN BY LYSINE GINGIPAIN

Periodontitis is a chronic inflammatory disease accompanied by alveolar bone resorption by osteoclasts. Porphyromonas gingivalis, an etiological agent for periodontitis, produces cysteine proteases called gingipains, which are classified based on their cleavage site specificity (i.e. arginine (Rgps)...

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Bibliographic Details
Main Authors: Akiyama, Tomohito, Miyamoto, Yoichi, Yoshimura, Kentaro, Yamada, Atsushi, Takami, Masamichi, Suzawa, Tetsuo, Hoshino, Marie, Imamura, Takahisa, Akiyama, Chie, Yasuhara, Rika, Mishima, Kenji, Maruyama, Toshifumi, Kohda, Chikara, Tanaka, Kazuo, Potempa, Jan, Yasuda, Hisataka, Baba, Kazuyoshi, Kamijo, Ryutaro
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140917/
https://ncbi.nlm.nih.gov/pubmed/24755218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520510
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