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Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis

The R- and K-gingipain proteases of Porphyromonas gingivalis are involved in proteolysis of haemoglobin from which the defensive dimeric haem pigment is formed. Whilst oxyhaemoglobin is refractory towards K-gingipain, methaemoglobin is rapidly degraded. Ligation of methaemoglobin with N(3)(−), which...

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Detalhes bibliográficos
Main Authors: Smalley, John W., Birss, Andrew J., Szmigielski, Borys, Potempa, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565508/
https://ncbi.nlm.nih.gov/pubmed/18713010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/BC.2008.XXX
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