Structure and Mechanism of Cysteine Peptidase Gingipain K (Kgp), a Major Virulence Factor of Porphyromonas gingivalis in Periodontitis

Cysteine peptidases are key proteolytic virulence factors of the periodontopathogen Porphyromonas gingivalis, which causes chronic periodontitis, the most prevalent dysbiosis-driven disease in humans. Two peptidases, gingipain K (Kgp) and R (RgpA and RgpB), which differ in their selectivity after ly...

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Vydáno v:J Biol Chem
Hlavní autoři: de Diego, Iñaki, Veillard, Florian, Sztukowska, Maryta N., Guevara, Tibisay, Potempa, Barbara, Pomowski, Anja, Huntington, James A., Potempa, Jan, Gomis-Rüth, F. Xavier
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231702/
https://ncbi.nlm.nih.gov/pubmed/25266723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602052
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