Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome

Skewing of the human oral microbiome causes dysbiosis and preponderance of bacteria such as Porphyromonas gingivalis, the main etiological agent of periodontitis. P. gingivalis secretes proteolytic gingipains (Kgp and RgpA/B) as zymogens inhibited by a pro-domain that is removed during extracellular...

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發表在:J Biol Chem
Main Authors: Pomowski, Anja, Usón, Isabel, Nowakowska, Zuzanna, Veillard, Florian, Sztukowska, Maryta N., Guevara, Tibisay, Goulas, Theodoros, Mizgalska, Danuta, Nowak, Magdalena, Potempa, Barbara, Huntington, James A., Potempa, Jan, Gomis-Rüth, F. Xavier
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2017
主題:
Protein Structure and Folding
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392567/
https://ncbi.nlm.nih.gov/pubmed/28196869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.776724
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