Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome

Skewing of the human oral microbiome causes dysbiosis and preponderance of bacteria such as Porphyromonas gingivalis, the main etiological agent of periodontitis. P. gingivalis secretes proteolytic gingipains (Kgp and RgpA/B) as zymogens inhibited by a pro-domain that is removed during extracellular...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Pomowski, Anja, Usón, Isabel, Nowakowska, Zuzanna, Veillard, Florian, Sztukowska, Maryta N., Guevara, Tibisay, Goulas, Theodoros, Mizgalska, Danuta, Nowak, Magdalena, Potempa, Barbara, Huntington, James A., Potempa, Jan, Gomis-Rüth, F. Xavier
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392567/
https://ncbi.nlm.nih.gov/pubmed/28196869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.776724
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