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Heparan Sulfate Containing Unsubstituted Glucosamine Residues: BIOSYNTHESIS AND HEPARANASE-INHIBITORY ACTIVITY

Degradation of heparan sulfate (HS) in the extracellular matrix by heparanase is linked to the processes of tumor invasion and metastasis. Thus, a heparanase inhibitor can be a potential anticancer drug. Because HS with unsubstituted glucosamine residues accumulates in heparanase-expressing breast c...

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Autors principals: Nadanaka, Satomi, Purunomo, Eko, Takeda, Naoko, Tamura, Jun-ichi, Kitagawa, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140882/
https://ncbi.nlm.nih.gov/pubmed/24753252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545343
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