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Regulation of Heparan Sulfate and Chondroitin Sulfate Glycosaminoglycan Biosynthesis by 4-Fluoro-glucosamine in Murine Airway Smooth Muscle Cells

The importance of the pathological changes in proteoglycans has driven the need to study and design novel chemical tools to control proteoglycan synthesis. Accordingly, we tested the fluorinated analogue of glucosamine (4-fluoro-N-acetyl-glucosamine (4-F-GlcNAc)) on the synthesis of heparan sulfate...

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Autori principali: Nigro, Julie, Wang, Aimin, Mukhopadhyay, Durba, Lauer, Mark, Midura, Ronald J., Sackstein, Robert, Hascall, Vincent C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719319/
https://ncbi.nlm.nih.gov/pubmed/19346253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002956
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