In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

Malaria is a preventable and treatable disease; yet half of the world's population lives at risk of infection, and an estimated 660,000 people die of malaria-related causes every year. Rising drug resistance threatens to make malaria untreatable, necessitating both the discovery of new antimala...

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Hlavní autoři: Ross, Leila S., Gamo, Francisco Javier, Lafuente-Monasterio, Maria José, Singh, Onkar M. P., Rowland, Paul, Wiegand, Roger C., Wirth, Dyann F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140291/
https://ncbi.nlm.nih.gov/pubmed/24782313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558353
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