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DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases

DNA topoisomerases control the topology of DNA. Type II topoisomerases exhibit topology simplification, whereby products of their reactions are simplified beyond that expected based on thermodynamic equilibrium. The molecular basis for this process is unknown, although DNA bending has been implicate...

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Autors principals: Thomson, Neil H., Santos, Sergio, Mitchenall, Lesley A., Stuchinskaya, Tanya, Taylor, James A., Maxwell, Anthony
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139952/
https://ncbi.nlm.nih.gov/pubmed/25142513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06158
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