How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of non-supercoiling type II topoisomerases

DNA topoisomerases control the topology of DNA (e.g. the level of supercoiling) in all cells. Type IIA topoisomerases are ATP-dependent enzymes that have been shown to simplify the topology of their DNA substrates to a level beyond that expected at equilibrium (i.e. more relaxed than the product of...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Stuchinskaya, Tanya, Mitchenall, Lesley A., Schoeffler, Allyn J., Corbett, Kevin D., Berger, James M., Bates, Andrew D., Maxwell, Anthony
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343537/
https://ncbi.nlm.nih.gov/pubmed/19094994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.11.056
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