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Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland

Conditional knock-out of Hif1a in the mouse mammary gland impairs lobuloalveolar differentiation during lactation. Here, we demonstrate that expression of ErbB4 was reduced in the lobulalveoli of mice with mammary gland-specific deletion of Hif1a. Erbb4 was not, however, a direct target gene for tra...

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Detalhes bibliográficos
Main Authors: Paatero, Ilkka, Seagroves, Tiffany N., Vaparanta, Katri, Han, Wen, Jones, Frank E., Johnson, Randall S., Elenius, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139252/
https://ncbi.nlm.nih.gov/pubmed/24966332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533497
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