SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase

Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase–activated signaling cascades. Previously, we have demonstrated that ErbB4 ICD is posttranslationally modified by the small...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Knittle, Anna M., Helkkula, Maria, Johnson, Mark S., Sundvall, Maria, Elenius, Klaus
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712627/
https://ncbi.nlm.nih.gov/pubmed/28974580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794271
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