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Excision of Uracil from Transcribed DNA Negatively Affects Gene Expression

Uracil is an unavoidable aberrant base in DNA, the repair of which takes place by a highly efficient base excision repair mechanism. The removal of uracil from the genome requires a succession of intermediate products, including an abasic site and a single strand break, before the original DNA struc...

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Autors principals: Lühnsdorf, Bork, Epe, Bernd, Khobta, Andriy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139217/
https://ncbi.nlm.nih.gov/pubmed/24951587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.521807
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