Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region

Oxidized DNA bases, particularly 7,8-dihydro-8-oxoguanine (8-oxoG), are endogenously generated in cells, being a cause of carcinogenic mutations and possibly interfering with gene expression. We found that expression of an oxidatively damaged plasmid DNA is impaired after delivery into human host ce...

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Hlavní autoři: Khobta, Andriy, Anderhub, Simon, Kitsera, Nataliya, Epe, Bernd
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910050/
https://ncbi.nlm.nih.gov/pubmed/20338881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq170
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