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Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region
Oxidized DNA bases, particularly 7,8-dihydro-8-oxoguanine (8-oxoG), are endogenously generated in cells, being a cause of carcinogenic mutations and possibly interfering with gene expression. We found that expression of an oxidatively damaged plasmid DNA is impaired after delivery into human host ce...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910050/ https://ncbi.nlm.nih.gov/pubmed/20338881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq170 |
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