Loading...

Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region

Oxidized DNA bases, particularly 7,8-dihydro-8-oxoguanine (8-oxoG), are endogenously generated in cells, being a cause of carcinogenic mutations and possibly interfering with gene expression. We found that expression of an oxidatively damaged plasmid DNA is impaired after delivery into human host ce...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Khobta, Andriy, Anderhub, Simon, Kitsera, Nataliya, Epe, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910050/
https://ncbi.nlm.nih.gov/pubmed/20338881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq170
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!