Impact of Diet-Induced Obesity on Intestinal Stem Cells: Hyperproliferation but Impaired Intrinsic Function That Requires Insulin/IGF1

Nutrient intake regulates intestinal epithelial mass and crypt proliferation. Recent findings in model organisms and rodents indicate nutrient restriction impacts intestinal stem cells (ISC). Little is known about the impact of diet-induced obesity (DIO), a model of excess nutrient intake on ISC. We...

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Bibliografiska uppgifter
Huvudupphovsmän: Mah, Amanda T., Van Landeghem, Laurianne, Gavin, Hannah E., Magness, Scott T., Lund, P. Kay
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2014
Ämnen:
Diabetes-Insulin-Glucagon-Gastrointestinal
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138564/
https://ncbi.nlm.nih.gov/pubmed/24914941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1112
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