Mechanism of Action of Glucagon-Like Peptide-2 to Increase IGF-I mRNA in Intestinal Subepithelial Fibroblasts

IGF-I, a known secretory product of intestinal subepithelial myofibroblasts (ISEMFs), is essential for the intestinotropic effects of glucagon-like peptide-2 (GLP-2). Furthermore, GLP-2 increases IGF-I mRNA transcript levels in vitro in heterogeneous fetal rat intestinal cultures, as well as in vivo...

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Detalhes bibliográficos
Main Authors: Leen, Jason L. S., Izzo, Angelo, Upadhyay, Chandani, Rowland, Katherine J., Dubé, Philip E., Gu, Steven, Heximer, Scott P., Rhodes, Christopher J., Storm, Daniel R., Lund, P. Kay, Brubaker, Patricia L.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Diabetes-Insulin-Glucagon-Gastrointestinal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384785/
https://ncbi.nlm.nih.gov/pubmed/21159855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0822
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