Mechanism of Action of Glucagon-Like Peptide-2 to Increase IGF-I mRNA in Intestinal Subepithelial Fibroblasts

IGF-I, a known secretory product of intestinal subepithelial myofibroblasts (ISEMFs), is essential for the intestinotropic effects of glucagon-like peptide-2 (GLP-2). Furthermore, GLP-2 increases IGF-I mRNA transcript levels in vitro in heterogeneous fetal rat intestinal cultures, as well as in vivo...

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Bibliographic Details
Main Authors: Leen, Jason L. S., Izzo, Angelo, Upadhyay, Chandani, Rowland, Katherine J., Dubé, Philip E., Gu, Steven, Heximer, Scott P., Rhodes, Christopher J., Storm, Daniel R., Lund, P. Kay, Brubaker, Patricia L.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2011
Subjects:
Diabetes-Insulin-Glucagon-Gastrointestinal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384785/
https://ncbi.nlm.nih.gov/pubmed/21159855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0822
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