Impact of Diet-Induced Obesity on Intestinal Stem Cells: Hyperproliferation but Impaired Intrinsic Function That Requires Insulin/IGF1

Nutrient intake regulates intestinal epithelial mass and crypt proliferation. Recent findings in model organisms and rodents indicate nutrient restriction impacts intestinal stem cells (ISC). Little is known about the impact of diet-induced obesity (DIO), a model of excess nutrient intake on ISC. We...

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Hauptverfasser: Mah, Amanda T., Van Landeghem, Laurianne, Gavin, Hannah E., Magness, Scott T., Lund, P. Kay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2014
Schlagworte:
Diabetes-Insulin-Glucagon-Gastrointestinal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138564/
https://ncbi.nlm.nih.gov/pubmed/24914941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1112
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