Impact of Diet-Induced Obesity on Intestinal Stem Cells: Hyperproliferation but Impaired Intrinsic Function That Requires Insulin/IGF1

Nutrient intake regulates intestinal epithelial mass and crypt proliferation. Recent findings in model organisms and rodents indicate nutrient restriction impacts intestinal stem cells (ISC). Little is known about the impact of diet-induced obesity (DIO), a model of excess nutrient intake on ISC. We...

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Detalles Bibliográficos
Main Authors: Mah, Amanda T., Van Landeghem, Laurianne, Gavin, Hannah E., Magness, Scott T., Lund, P. Kay
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2014
Assuntos:
Diabetes-Insulin-Glucagon-Gastrointestinal
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138564/
https://ncbi.nlm.nih.gov/pubmed/24914941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1112
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