Impact of Diet-Induced Obesity on Intestinal Stem Cells: Hyperproliferation but Impaired Intrinsic Function That Requires Insulin/IGF1

Nutrient intake regulates intestinal epithelial mass and crypt proliferation. Recent findings in model organisms and rodents indicate nutrient restriction impacts intestinal stem cells (ISC). Little is known about the impact of diet-induced obesity (DIO), a model of excess nutrient intake on ISC. We...

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Autores principales: Mah, Amanda T., Van Landeghem, Laurianne, Gavin, Hannah E., Magness, Scott T., Lund, P. Kay
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2014
Materias:
Diabetes-Insulin-Glucagon-Gastrointestinal
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138564/
https://ncbi.nlm.nih.gov/pubmed/24914941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1112
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