A roadmap to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Kinases are principal components of signal transduction pathways and the focus of intense basic and drug discovery research. Irreversible inhibitors that covalently modify non-catalytic cysteines in kinase active-sites have emerged as valuable probes and approved drugs. Many protein classes, however...

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Detalhes bibliográficos
Main Authors: Lanning, Bryan R., Whitby, Landon R., Dix, Melissa M., Douhan, John, Gilbert, Adam M., Hett, Erik C., Johnson, Theodore O., Joslyn, Chris, Kath, John C., Niessen, Sherry, Roberts, Lee R., Schnute, Mark E., Wang, Chu, Hulce, Jonathan J., Wei, Baoxian, Whiteley, Laurence O., Hayward, Matthew M., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138289/
https://ncbi.nlm.nih.gov/pubmed/25038787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1582
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