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Metabolically labile fumarate esters impart kinetic selectivity to irreversible inhibitors
Electrophilic small molecules are an important class of chemical probes and drugs that produce biological effects by irreversibly modifying proteins. Examples of electrophilic drugs include covalent kinase inhibitors that are used to treat cancer and the multiple sclerosis drug dimethyl fumarate. Op...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5273863/ https://ncbi.nlm.nih.gov/pubmed/27960302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b10589 |
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