A roadmap to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Kinases are principal components of signal transduction pathways and the focus of intense basic and drug discovery research. Irreversible inhibitors that covalently modify non-catalytic cysteines in kinase active-sites have emerged as valuable probes and approved drugs. Many protein classes, however...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Lanning, Bryan R., Whitby, Landon R., Dix, Melissa M., Douhan, John, Gilbert, Adam M., Hett, Erik C., Johnson, Theodore O., Joslyn, Chris, Kath, John C., Niessen, Sherry, Roberts, Lee R., Schnute, Mark E., Wang, Chu, Hulce, Jonathan J., Wei, Baoxian, Whiteley, Laurence O., Hayward, Matthew M., Cravatt, Benjamin F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138289/
https://ncbi.nlm.nih.gov/pubmed/25038787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1582
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items