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Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture

The network of activator protein-protein interactions (PPIs) that underpin transcription initiation is poorly defined, particularly in the cellular context. The transient nature of these contacts and the often low abundance of the participants present significant experimental hurdles. Through the co...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Dugan, Amanda, Majmudar, Chinmay Y., Pricer, Rachel, Niessen, Sherry, Lancia, Jody K., Fung, Hugo Yik-Hong, Cravatt, Benjamin F., Mapp, Anna K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217703/
https://ncbi.nlm.nih.gov/pubmed/27611834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b07680
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