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Electron‐deficient p‐benzoyl‐l‐phenylalanine derivatives increase covalent chemical capture yields for protein–protein interactions

The photoactivatable amino acid p‐benzoyl‐l‐phenylalanine (pBpa) has been used for the covalent capture of protein–protein interactions (PPIs) in vitro and in living cells. However, this technique often suffers from poor photocrosslinking yields due to the low reactivity of the active species. Here...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Joiner, Cassandra M., Breen, Meghan E., Mapp, Anna K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511736/
https://ncbi.nlm.nih.gov/pubmed/30977234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3621
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