Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosom...

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Detalhes bibliográficos
Main Authors: Gidon, Alexandre, Al-Bataineh, Mohammad M., Jean-Alphonse, Frederic G., Stevenson, Hilary, Watanabe, Tomoyuki, Louet, Claire, Khatri, Ashok, Calero, Guillermo, Pastor-Soler, Núria M., Gardella, Thomas J., Vilardaga, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138287/
https://ncbi.nlm.nih.gov/pubmed/25064832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1589
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