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Challenges and opportunities in targeting the menin-MLL interaction

Menin is an essential co-factor of oncogenic MLL fusion proteins and the menin-MLL interaction is critical for development of acute leukemia in vivo. Targeting the menin-MLL interaction with small molecules represents an attractive strategy to develop new anticancer agents. Recent developments, incl...

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Autors principals: Cierpicki, Tomasz, Grembecka, Jolanta
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138051/
https://ncbi.nlm.nih.gov/pubmed/24635524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.13.214
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