Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

Newly designed bivalent ligands—opioid agonist/NK1-antagonists have been synthesized. The synthesis of new starting materials—carboxy-derivatives of Fentanyl (1a–1c) was developed. These products have been transformed to ‘isoimidium perchlorates’ (2a–c). The new isoimidium perchlorates have been suc...

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Autors principals: Vardanyan, Ruben, Kumirov, Vlad K., Nichol, Gary S., Davis, Peg, Liktor-Busa, Erika, Rankin, David, Varga, Eva, Vanderah, Todd, Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137774/
https://ncbi.nlm.nih.gov/pubmed/21925887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.027
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