The Biological Activity and Metabolic Stability of Peptidic Bifunctional Compounds That Are Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists with A Cystine Moiety

In order to improve metabolic stability, a ring structure with a cystine moiety was introduced into TY027 (Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-[3’,5’-(CF(3))(2)Bzl]), which is a lead compound of our developing bifunctional peptide possessing opioid agonist and NK1 antagonist activities. TY038 (Tyr-...

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Detaylı Bibliyografya
Asıl Yazarlar: Yamamoto, Takashi, Nair, Padma, Ma, Shou-wu, Davis, Peg, Yamamura, Henry I., Vanderah, Todd W., Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775479/
https://ncbi.nlm.nih.gov/pubmed/19762245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.08.035
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