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Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain

Several studies have suggested functional association between μ-opioid and δ-opioid receptors and showed that μ-activity could be modulated by δ-ligands. The general conclusion is that agonists for the δ-receptor can enhance the analgesic potency and efficacy of μ-agonists. Our preliminary investiga...

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Detalhes bibliográficos
Publicado no:J Heterocycl Chem
Main Authors: Vardanyan, Ruben S., Cain, James P., Haghighi, Saghar Mowlazadeh, Kumirov, Vlad K., McIntosh, Mary I., Sandweiss, Alexander J., Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557416/
https://ncbi.nlm.nih.gov/pubmed/28819330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jhet.2696
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