CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

The Nef gene product is a regulatory protein of HIV whose biological function is poorly understood. Nef has been thought to have a negative effect on viral replication in vitro but has been shown in studies with SIV to be necessary in the establishment of viraemia in vivo. In vitro studies in variou...

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Bibliographische Detailangaben
Veröffentlicht in:EMBO J
Hauptverfasser: Brady, H J, Pennington, D J, Miles, C G, Dzierzak, E A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1993
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413753/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8262036/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06186.x
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