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CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.
The Nef gene product is a regulatory protein of HIV whose biological function is poorly understood. Nef has been thought to have a negative effect on viral replication in vitro but has been shown in studies with SIV to be necessary in the establishment of viraemia in vivo. In vitro studies in variou...
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| Pubblicato in: | EMBO J |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
1993
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8262036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb06186.x |
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