Structural Basis of CD4 Downregulation by HIV-1 Nef

The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote viral pathogenesis and is an attractive target for the development of novel therapeutics. A key function of Nef is to remove the CD4 receptor from the cell surface by hijacking clathrin- and AP2-dependent endocytosis...

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Publié dans:Nat Struct Mol Biol
Auteurs principaux: Kwon, Yonghwa, Kaake, Robyn M., Echeverria, Ignacia, Suarez, Marissa, Shamsabadi, Mohammad Karimian, Stoneham, Charlotte, Ramirez, Peter W., Kress, Jacob, Singh, Rajendra, Sali, Andrej, Krogan, Nevan, Guatelli, John, Jia, Xiaofei
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483821/
https://ncbi.nlm.nih.gov/pubmed/32719457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0463-z
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