Pyrrolobenzodiazepines (PBDs) Do Not Bind to DNA G-Quadruplexes

The pyrrolo[2,1-c][1,4] benzodiazepines (PBDs) are a family of sequence-selective, minor-groove binding DNA-interactive agents that covalently attach to guanine residues. A recent publication in this journal (Raju et al, PloS One, 2012, 7, 4, e35920) reported that two PBD molecules were observed to...

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Detaylı Bibliyografya
Asıl Yazarlar: Rahman, Khondaker M., Corcoran, David B., Bui, Tam T. T., Jackson, Paul J. M., Thurston, David E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136862/
https://ncbi.nlm.nih.gov/pubmed/25133504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105021
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