Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

[Image: see text] The ubiquitin-proteasome system (UPS) is a potential pathway for therapeutic intervention for pathogens such as Plasmodium, the causative agent of malaria. However, due to the essential nature of this proteolytic pathway, proteasome inhibitors must avoid inhibition of the host enzy...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Li, Hao, van der Linden, Wouter A., Verdoes, Martijn, Florea, Bogdan I., McAllister, Fiona E., Govindaswamy, Kavitha, Elias, Joshua E., Bhanot, Purnima, Overkleeft, Herman S., Bogyo, Matthew
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2014
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136710/
https://ncbi.nlm.nih.gov/pubmed/24918547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5001263
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