Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

[Image: see text] The ubiquitin-proteasome system (UPS) is a potential pathway for therapeutic intervention for pathogens such as Plasmodium, the causative agent of malaria. However, due to the essential nature of this proteolytic pathway, proteasome inhibitors must avoid inhibition of the host enzy...

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Detalhes bibliográficos
Main Authors: Li, Hao, van der Linden, Wouter A., Verdoes, Martijn, Florea, Bogdan I., McAllister, Fiona E., Govindaswamy, Kavitha, Elias, Joshua E., Bhanot, Purnima, Overkleeft, Herman S., Bogyo, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136710/
https://ncbi.nlm.nih.gov/pubmed/24918547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5001263
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