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Rational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine Detoxification
[Image: see text] Cocaine esterase (CocE) is known as the most efficient natural enzyme for cocaine hydrolysis. The major obstacle to the clinical application of wild-type CocE is the thermoinstability with a half-life of only ∼12 min at 37 °C. The previously designed T172R/G173Q mutant (denoted as...
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| Glavni autori: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
|
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136690/ https://ncbi.nlm.nih.gov/pubmed/24919140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500257s |
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