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Kinetic Characterization of High-Activity Mutants of Human Butyrylcholinesterase for Cocaine Metabolite Norcocaine
It has been known that cocaine produces the toxic and physiological effects through not only cocaine itself but also norcocaine formed from cocaine oxidation catalyzed by microsomal cytochrome P450 3A4 in the human liver. The catalytic parameters (k(cat) and K(M)) of human butyrylcholinesterase (BCh...
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| Publicado no: | Biochem J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372247/ https://ncbi.nlm.nih.gov/pubmed/24125115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131100 |
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