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Protein Quality Control During Erythropoiesis and Hemoglobin Synthesis
Erythrocytes must regulate hemoglobin synthesis to limit the toxicities of unstable free globin chain subunits. This is particularly relevant in β-thalassemia, where β globin deficiency causes accumulation of free α globin, which forms intracellular precipitates that destroy erythroid precursors. Ex...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136498/ https://ncbi.nlm.nih.gov/pubmed/21075281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hoc.2010.08.013 |
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