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Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia
Excess free α-globin is cytotoxic and contributes to the pathophysiology of β-thalassemia. Alpha hemoglobin stabilizing protein (AHSP) is a molecular chaperone that binds free α-globin to promote its folding and inhibit its ability to produce damaging reactive oxygen species. Reduced AHSP levels cor...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632304/ https://ncbi.nlm.nih.gov/pubmed/20815047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21829 |
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