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Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia

Cells remove unstable polypeptides through protein quality-control (PQC) pathways such as ubiquitin-mediated proteolysis and autophagy. In the present study, we investigated how these pathways are used in β-thalassemia, a common hemoglobinopathy in which β-globin gene mutations cause the accumulatio...

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Detalhes bibliográficos
Main Authors: Khandros, Eugene, Thom, Christopher S., D'Souza, Janine, Weiss, Mitchell J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369615/
https://ncbi.nlm.nih.gov/pubmed/22427201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-397729
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