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Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia
Cells remove unstable polypeptides through protein quality-control (PQC) pathways such as ubiquitin-mediated proteolysis and autophagy. In the present study, we investigated how these pathways are used in β-thalassemia, a common hemoglobinopathy in which β-globin gene mutations cause the accumulatio...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3369615/ https://ncbi.nlm.nih.gov/pubmed/22427201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-397729 |
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