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The Herpes Simplex Virus 1 Virion Host Shutoff Protein Enhances Translation of Viral Late mRNAs by Preventing mRNA Overload

We recently demonstrated that the virion host shutoff (vhs) protein, an mRNA-specific endonuclease, is required for efficient herpes simplex virus 1 (HSV-1) replication and translation of viral true-late mRNAs, but not other viral and cellular mRNAs, in many cell types (B. Dauber, J. Pelletier, and...

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Autors principals: Dauber, Bianca, Saffran, Holly A., Smiley, James R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136367/
https://ncbi.nlm.nih.gov/pubmed/24920814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01350-14
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