Chikungunya Viruses That Escape Monoclonal Antibody Therapy Are Clinically Attenuated, Stable, and Not Purified in Mosquitoes

Chikungunya virus (CHIKV) is a reemerging mosquito-transmitted alphavirus that causes epidemics of debilitating polyarthritis in humans. A prior study identified two anti-CHIKV monoclonal antibodies ([MAbs] CHK-152 and CHK-166) against the E2 and E1 structural proteins, which had therapeutic efficac...

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Autori principali: Pal, Pankaj, Fox, Julie M., Hawman, David W., Huang, Yan-Jang S., Messaoudi, Ilhem, Kreklywich, Craig, Denton, Michael, Legasse, Alfred W., Smith, Patricia P., Johnson, Syd, Axthelm, Michael K., Vanlandingham, Dana L., Streblow, Daniel N., Higgs, Stephen, Morrison, Thomas E., Diamond, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135940/
https://ncbi.nlm.nih.gov/pubmed/24829346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01032-14
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