Chikungunya Viruses That Escape Monoclonal Antibody Therapy Are Clinically Attenuated, Stable, and Not Purified in Mosquitoes

Chikungunya virus (CHIKV) is a reemerging mosquito-transmitted alphavirus that causes epidemics of debilitating polyarthritis in humans. A prior study identified two anti-CHIKV monoclonal antibodies ([MAbs] CHK-152 and CHK-166) against the E2 and E1 structural proteins, which had therapeutic efficac...

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Main Authors: Pal, Pankaj, Fox, Julie M., Hawman, David W., Huang, Yan-Jang S., Messaoudi, Ilhem, Kreklywich, Craig, Denton, Michael, Legasse, Alfred W., Smith, Patricia P., Johnson, Syd, Axthelm, Michael K., Vanlandingham, Dana L., Streblow, Daniel N., Higgs, Stephen, Morrison, Thomas E., Diamond, Michael S.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2014
主題:
Pathogenesis and Immunity
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135940/
https://ncbi.nlm.nih.gov/pubmed/24829346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01032-14
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