Chikungunya Viruses That Escape Monoclonal Antibody Therapy Are Clinically Attenuated, Stable, and Not Purified in Mosquitoes

Chikungunya virus (CHIKV) is a reemerging mosquito-transmitted alphavirus that causes epidemics of debilitating polyarthritis in humans. A prior study identified two anti-CHIKV monoclonal antibodies ([MAbs] CHK-152 and CHK-166) against the E2 and E1 structural proteins, which had therapeutic efficac...

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Autors principals: Pal, Pankaj, Fox, Julie M., Hawman, David W., Huang, Yan-Jang S., Messaoudi, Ilhem, Kreklywich, Craig, Denton, Michael, Legasse, Alfred W., Smith, Patricia P., Johnson, Syd, Axthelm, Michael K., Vanlandingham, Dana L., Streblow, Daniel N., Higgs, Stephen, Morrison, Thomas E., Diamond, Michael S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135940/
https://ncbi.nlm.nih.gov/pubmed/24829346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01032-14
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