Chikungunya Viruses That Escape Monoclonal Antibody Therapy Are Clinically Attenuated, Stable, and Not Purified in Mosquitoes

Chikungunya virus (CHIKV) is a reemerging mosquito-transmitted alphavirus that causes epidemics of debilitating polyarthritis in humans. A prior study identified two anti-CHIKV monoclonal antibodies ([MAbs] CHK-152 and CHK-166) against the E2 and E1 structural proteins, which had therapeutic efficac...

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Detalhes bibliográficos
Main Authors: Pal, Pankaj, Fox, Julie M., Hawman, David W., Huang, Yan-Jang S., Messaoudi, Ilhem, Kreklywich, Craig, Denton, Michael, Legasse, Alfred W., Smith, Patricia P., Johnson, Syd, Axthelm, Michael K., Vanlandingham, Dana L., Streblow, Daniel N., Higgs, Stephen, Morrison, Thomas E., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135940/
https://ncbi.nlm.nih.gov/pubmed/24829346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01032-14
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